Blar i forfatter "Mancusi, Costantino"
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Cardiac adaptation to hypertension in adult female Dahl salt-sensitive rats is dependent on ovarian function, but loss of ovarian function does not predict early maladaptation
Ludvigsen, Stian; Mancusi, Costantino; Kildal, Simon; de Simone, Giovanni; Gerdts, Eva; Ytrehus, Kirsti (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-08)Aim of study was to examine experimentally the adult female hypertensive heart in order to determine the role of ovary function in the response of the heart to salt-dependent hypertension. Dahl salt-sensitive rats, age 12 weeks, with/without ovariectomy were fed a standard (0.3% NaCl) or high-salt diet (8%) for 16 weeks. Mean arterial blood pressure monitored noninvasively in conscious state ... -
Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat
Ytrehus, Kirsti; Ludvigsen, Stian; Mancusi, Costantino; Gerdts, Eva; de Simone, Giovanni (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-19)Angiotensin-converting enzyme 2 (ACE 2) in the heart including its sex dependency in the hypertensive heart, has not been much studied compared to ACE. In the present study, we used the Dahl salt-sensitive rat exposed to fructose and salt to model a hypertensive phenotype in males, females, and ovariectomized females. Blood pressure was measured by the tale-cuff technique in the conscious state. ...